We study the biology of Mycobacterium tuberculosis and HIV-1 infections in the context of our evolving appreciation of myeloid cell heterogeneity in vivo. Our studies extend to human subject analysis in Malawi and South ...
Read More
The lab studies host-pathogen interactions, focusing on macrophages and Mycobacterium tuberculosis (Mtb). Most projects in the lab today fall into one or more of the following broad topics: host pathways controlling susceptibility and resistance ...
Read More
My lab is interested in host-cell-virus interactions. We primarily study mammalian orthoreoviruses. Current projects include: mechanisms of viral compartmentalization and commandeering of the host translational machinery; viral mechanisms of counteracting the innate immune response; ...
Read More
Our work has focused on the molecular events important for immune cell development and function with a particular interest in the signaling events initiated by surface receptor engagement. We have been particularly interested in ...
Read More
There is a fine balance between appropriate, host-protective, immune responses and dysregulated autoimmune and pathologic inflammation. The Leifer lab investigates how immune responses are induced and regulated with the hope of developing treatments to ...
Read More
We investigate (1) how UBR5, a novel protein ubiquitin ligase frequently altered in human cancers, promotes tumor metastasis by regulating epithelial to mesenchymal transition (EMT) in a cell intrinsic manner;(2) to identify UBR5’s E3 ...
Read More
The lab is interested in the pathogenesis of Mycobacterium tuberculosis and explores the mechanisms by which this pathogen establishes and maintains persistent infections.
We are interested in the genetic and environmental factors that regulate regulatory lymphocyte development and function, and how they interact to regulate immune homeostasis.
The main focus of my research program is to elucidate key components in enveloped viruses and their host cells that: 1] mediate viral entry into cells, 2] elicit cell immune responses, and 3] mediate ...
Read More
We are interested in the role of Tyrosine Kinases (TKs) in regulating the immune response, with the goal of using this information to manipulate immune responses. We are specifically interested in the Tec families ...
Read More
