Xiaojing Ma
Professor
Microbiology & Immunology
Weill Cornell Medical - New York City
Interests: Cancer Metastasis, Dendritic Cells, Macrophages, Neoantigens, T Lymphocytes, Tumor Immunology, Ubiquitin Ligase
We investigate (1) how UBR5, a novel protein ubiquitin ligase frequently altered in human cancers, promotes tumor metastasis by regulating epithelial to mesenchymal transition (EMT) in a cell intrinsic manner;(2) to identify UBR5’s E3 ligase substrates and interacting protein partners; (3) to identify potential “neoantigens†induced in UBR5-deficient tumors that trigger T cell responses for future cancer vaccine development and immunotherapy; (4) to identify prototypical molecular “degraders†of UBR5 via Proteolysis Targeting Chimera (PROTAC).
