Microbiology & Immunology
College of Veterinary Medicine - Ithaca
Interests: Immunoengineering, Infection, Inflammation, Innate Immunity, Vaccines
There is a fine balance between appropriate, host-protective, immune responses and dysregulated autoimmune and pathologic inflammation. The Leifer lab investigates how immune responses are induced and regulated with the hope of developing treatments to improve host defense and vaccines, or to limit autoimmune pathology. We use macrophages and the Toll-like receptors that they express to initiate these responses as a model system to investigate microenvironmental and intracellular regulatory mechanisms.