I study primary macrophages as targets of viral infection, including HIV and SARS-CoV2. I am using advanced ex vivo analyses, unbiased and targeted molecular profiling and mouse genetics to dissect the roles of macrophages ...
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Regulation of Immunity at Tissue Sites of Infection and Autoimmunity.
The structure and function of viral envelope proteins, how genomic mutations lead to changes in the envelope proteins and control viral pathogenesis in influenza viruses and coronaviruses,SARS-CoV, MERS-CoV and feline coronaviruses; novel vaccines and ...
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The lab studies host-pathogen interactions, focusing on macrophages and Mycobacterium tuberculosis (Mtb). Most projects in the lab today fall into one or more of the following broad topics: host pathways controlling susceptibility and resistance ...
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My lab is interested in host-cell-virus interactions. We primarily study mammalian orthoreoviruses. Current projects include: mechanisms of viral compartmentalization and commandeering of the host translational machinery; viral mechanisms of counteracting the innate immune response; ...
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We study viruses of animals, focusing on those that have jumped from one host to another. The main subjects of study include the canine parvovirus, which emerged in 1978 to cause a pandemic in ...
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My lab is focused on understanding basic principles of immunity against infection and age-related changes that alter immune responses in early life. We also are interested in determining how environmental factors (maternal diet, microbiome, ...
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We study the biology of Mycobacterium tuberculosis and HIV-1 infections in the context of our evolving appreciation of myeloid cell heterogeneity in vivo. Our studies extend to human subject analysis in Malawi and South ...
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There is a fine balance between appropriate, host-protective, immune responses and dysregulated autoimmune and pathologic inflammation. The Leifer lab investigates how immune responses are induced and regulated with the hope of developing treatments to ...
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