Medicine, Microbiology & Immunology
Weill Cornell Medical - Ithaca
Interests: Adapter Proteins, Cancer Immunotherapy, Immune Development, Signal Transduction, T Cells
Our work has focused on the molecular events important for immune cell development and function with a particular interest in the signaling events initiated by surface receptor engagement. We have been particularly interested in how adapter proteins nucleate multi molecular complexes that regulate, both positively and negatively, immune cell activation. Most recently, we have explored the impact of modulating key signaling pathways in the host response to malignancy.