Microbiology & Immunology
College of Veterinary Medicine - Ithaca
Interests: Antibody, Host Range, Infectious Disease, Viral Assembly, Viral Entry, Viral Immunology, Virus/Virology, Wildlife
We study viruses of animals, focusing on those that have jumped from one host to another. The main subjects of study include the canine parvovirus, which emerged in 1978 to cause a pandemic in dogs, and the canine H3N8 and H3N2 influenza viruses. We examine the evolution, structures, and virus:host interactions, in particular those that control host range. A focus is on the virus:receptor interactions, in particular the transferrin receptor and sialic acids. We also study the antibody responses to these viruses, including the structures of antibodies bound to viral antigens.