Dr. Ivashkiv’s laboratory investigates the pathogenic mechanisms of cytokines in inflammatory and musculoskeletal conditions such as rheumatoid arthritis, osteolysis and orthopaedic implant loosening/failure, and systemic lupus erythematosus. He is interested in how cytokines and ...
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To advance our understanding of the relationship between HIV and the human immune system primarily cytotoxic T-cells and natural killer cells.
(1) Histone functional genetic models to study epigenetic regulation of mouse hematopoiesis and immune cell development. (2) Mechanisms and function of epigenetic memory of inflammation in hematopoietic stem cells. (3) “Signaling to chromatin” and ...
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I am interested in the microbiome and how it impacts efficacy of immunotherapy and radiation. I am also studying prostate SBRT.
Work in my laboratory is currently addressing the molecular mechanisms that are responsible for the increased antigenicity and adjuvanticity of cancer cells in irradiated tumors. We have recently identified mutation-generated CD8 T cell epitopes ...
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My long-term goal as a physician-scientist is to explore differential human immune responses to mycobacterial pathogens, including Mycobacterium tuberculosis and M. leprae.
The lab is interested in the pathogenesis of Mycobacterium tuberculosis and explores the mechanisms by which this pathogen establishes and maintains persistent infections.
The Institute’s three main resources that enable the EIPM team to most efficiently match new, biologically-targeted therapies to patients who need it are next-generation genomics, biobanking, and computational biology. Our physician-scientists use the most ...
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The primary focus of my research is to understand the mechanical and metabolic drivers of immunity to enhance immunotherapeutic approaches to infectious diseases and cancer. Integration of immunometabolism and cellular mechanics underpins how cells ...
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The human microbiota, including the microbes living on/in the human body, modulates host biology in multiple ways. My research aims to study the chemistry and biology behind microbe-host interactions in the context of health ...
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