Archives

Lyden

David Lyden

My laboratory has focused much of its recent activity on understanding the role of tumor-secreted exosomes in cancer metastasis (Nature Medicine, 2012; Nature Cell Biology, 2015; Nature, 2015; Cancer Cell, 2016). My lab’s current ...
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Ma

Xiaojing Ma

We investigate (1) how UBR5, a novel protein ubiquitin ligase frequently altered in human cancers, promotes tumor metastasis by regulating epithelial to mesenchymal transition (EMT) in a cell intrinsic manner;(2) to identify UBR5’s E3 ...
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Matei

My research focuses on deciphering the role of exosomes in mediating the crosstalk between the host immune system and the tumor, and the mechanisms through which exosomes coax the immune system to contribute to ...
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McGraw

Insulin regulates the storage of dietary glucose by stimulating its uptake into muscle and fat. Insulin increases glucose uptake into these cells by recruiting vesicles containing the GLUT4 glucose transporter to the cell surface. ...
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Ivashkiv

Lionel Ivashkiv

Dr. Ivashkiv’s laboratory investigates the pathogenic mechanisms of cytokines in inflammatory and musculoskeletal conditions such as rheumatoid arthritis, osteolysis and orthopaedic implant loosening/failure, and systemic lupus erythematosus. He is interested in how cytokines and ...
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Jones

Brad Jones

To advance our understanding of the relationship between HIV and the human immune system primarily cytotoxic T-cells and natural killer cells.

Demaria

Sandra Demaria

Work in my laboratory is currently addressing the molecular mechanisms that are responsible for the increased antigenicity and adjuvanticity of cancer cells in irradiated tumors. We have recently identified mutation-generated CD8 T cell epitopes ...
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Dupnik

Kate Dupnik

My long-term goal as a physician-scientist is to explore differential human immune responses to mycobacterial pathogens, including Mycobacterium tuberculosis and M. leprae.

Ehrt

Sabine Ehrt

The lab is interested in the pathogenesis of Mycobacterium tuberculosis and explores the mechanisms by which this pathogen establishes and maintains persistent infections.

Elemento

Olivier Elemento

The Institute’s three main resources that enable the EIPM team to most efficiently match new, biologically-targeted therapies to patients who need it are next-generation genomics, biobanking, and computational biology. Our physician-scientists use the most ...
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