Hospital for Special Surgery - New York City
Interests: Cytokines, Epigenomics, Macrophages, Rheumatoid Arthritis, Signaling
Dr. Ivashkiv’s laboratory investigates the pathogenic mechanisms of cytokines in inflammatory and musculoskeletal conditions such as rheumatoid arthritis, osteolysis and orthopaedic implant loosening/failure, and systemic lupus erythematosus. He is interested in how cytokines and inflammatory factors regulate the activation and function of innate immune and stromal cells, with a focus on macrophages, osteoclasts, and synovial fibroblasts. Macrophages play key roles in inflammation and tissue damage/repair, osteoclasts destroy bone, and synovial fibroblasts contribute to arthritis. Cytokines are key regulators of these cells and of immune responses important in inflammatory and musculoskeletal diseases. Cytokines determine the severity of inflammation and the extent of associated tissue damage and/or repair. The Ivashkiv laboratory studies cytokine signaling, mechanisms of cytokine production, and epigenetic regulation of inflammatory gene expression to discover new mechanisms and therapeutic targets for inflammatory and musculoskeletal diseases.