Immune memory occurs when the immune system remembers previous encounters with pathogens, aberrant cells, or self-antigens to produce a more rapid or robust secondary response upon re-encounter. It stands as the cornerstone of vaccine ...
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Although immune checkpoint blockade therapy has revolutionized cancer treatment, a subset of tumors, such as those of the breast, are still largely unresponsive. The Dongre Lab is focused on understanding mechanisms that can potentiate ...
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Dr. Fowell’s laboratory’s research focuses on the spatiotemporal regulation of T cell immunity at tissues sites of infection and inflammation. The rapid response of the immune system to tissue damage and infection is reliant ...
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We are testing a nanomedical approach, based on gold-nanoparticles, for HIV eradication in vitro, in human PBMCs, and in a pre-clinical model in vivo.
Our laboratory studies “tissue homeostasis” the deliberate and balanced equilibrium that the immune system must achieve in order to both enforce self-tolerance to our own tissues, while at the same time remaining poised to ...
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Extensive scientific background in immunology and infectious disease, having worked with T-cells in the context of mycobacterial infection
We study how gene expression patterns are encoded in Metazoan DNA sequence, and how these patterns contribute to evolution, development, and disease.
Development of the adaptive immune response and integration of DNA damage responses and immune responses.
The focus and long-term research goals of the Sonnenberg Laboratory are to interrogate the mechanisms that maintain a state of health in the human gastrointestinal tract. Ongoing research in the Sonnenberg Laboratory aims to ...
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