College of Veterinary Medicine - Ithaca
Interests: Cancer - Breast, Epithelial-to-Mesenchymal Transition, Immune checkpoint blockade, Immunosuppression, T Cells, Tumor Microenvironment
Although immune checkpoint blockade therapy has revolutionized cancer treatment, a subset of tumors, such as those of the breast, are still largely unresponsive. The Dongre Lab is focused on understanding mechanisms that can potentiate the efficacy of immune checkpoint blockade therapy in the context of poorly responding tumors. We specifically focus on understanding how the Epithelial-to-Mesenchymal Transition (EMT), a cell-biological process that is associated with metastatic dissemination, contributes to immunosuppression and resistance to checkpoint blockade immunotherapies in the context of breast carcinomas.