The human microbiota, including the microbes living on/in the human body, modulates host biology in multiple ways. My research aims to study the chemistry and biology behind microbe-host interactions in the context of health ...
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My primary research interest is the identification of novel therapeutic approaches for targeting leukemia stem cells (LSCs) without harming normal hematopoietic stem cells (HSCs).
Work in my laboratory is currently addressing the molecular mechanisms that are responsible for the increased antigenicity and adjuvanticity of cancer cells in irradiated tumors. We have recently identified mutation-generated CD8 T cell epitopes ...
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My long-term goal as a physician-scientist is to explore differential human immune responses to mycobacterial pathogens, including Mycobacterium tuberculosis and M. leprae.
The lab is interested in the pathogenesis of Mycobacterium tuberculosis and explores the mechanisms by which this pathogen establishes and maintains persistent infections.
I am currently interested in employing predictive approaches (primarily through integrated analyses of public genomic datasets) that can be applied to various topics in cancer. These topics include: a) prediction of molecular markers for ...
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The main interest of the lab is centered on the basic understanding of nucleic acid recognition in autoimmunity and in particular on the potential clinical benefit of interfering with TLR signaling in human diseases. ...
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The Blander Laboratory studies the mechanisms by which the innate immune system detects and responds to perturbations in homeostasis at the molecular, cellular and organismal level. We study these responses in the context of ...
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I am interested in immune tolerance and it’s impact on T cell effector function. My goal is to investigate immunotherapeutics for cancer. In particular, these interests are centered around combinatorial applications of immunotherapy and ...
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We study the genetic links between cancer mortality and ancestry, particularly African ancestry in the context of cancer disparities. Currently, we are investigating the distinct tumor immuno-phenotypes we have discovered in breast cancer, related ...
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