Work in my laboratory is currently addressing the molecular mechanisms that are responsible for the increased antigenicity and adjuvanticity of cancer cells in irradiated tumors. We have recently identified mutation-generated CD8 T cell epitopes ...
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My long-term goal as a physician-scientist is to explore differential human immune responses to mycobacterial pathogens, including Mycobacterium tuberculosis and M. leprae.
The lab is interested in the pathogenesis of Mycobacterium tuberculosis and explores the mechanisms by which this pathogen establishes and maintains persistent infections.
The Institute’s three main resources that enable the EIPM team to most efficiently match new, biologically-targeted therapies to patients who need it are next-generation genomics, biobanking, and computational biology. Our physician-scientists use the most ...
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The primary focus of my research is to understand the mechanical and metabolic drivers of immunity to enhance immunotherapeutic approaches to infectious diseases and cancer. Integration of immunometabolism and cellular mechanics underpins how cells ...
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The human microbiota, including the microbes living on/in the human body, modulates host biology in multiple ways. My research aims to study the chemistry and biology behind microbe-host interactions in the context of health ...
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My primary research interest is the identification of novel therapeutic approaches for targeting leukemia stem cells (LSCs) without harming normal hematopoietic stem cells (HSCs).
We study the genetic links between cancer mortality and ancestry, particularly African ancestry in the context of cancer disparities. Currently, we are investigating the distinct tumor immuno-phenotypes we have discovered in breast cancer, related ...
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I am currently interested in employing predictive approaches (primarily through integrated analyses of public genomic datasets) that can be applied to various topics in cancer. These topics include: a) prediction of molecular markers for ...
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The main interest of the lab is centered on the basic understanding of nucleic acid recognition in autoimmunity and in particular on the potential clinical benefit of interfering with TLR signaling in human diseases. ...
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