We study the biology of Mycobacterium tuberculosis and HIV-1 infections in the context of our evolving appreciation of myeloid cell heterogeneity in vivo. Our studies extend to human subject analysis in Malawi and South ...
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My lab develops and uses advanced optical techniques to observe and manipulate in vivo biological systems, with the goal of constructing a microscopic-scale understanding of normal and disease-state physiological processes in the central nervous ...
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My lab studies mechanisms of genome maintenance and consequences of genome instability. Such consequences include cancer, cellular senescence, impacts on stem cells, and lethal levels of inflammation.
Our research is focused on understanding, at the biochemical, molecular and cellular levels, how plants protect themselves against microbial pathogens. The major goal is to determine the mechanisms of action of salicylic acid (SA) ...
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Our work has focused on the molecular events important for immune cell development and function with a particular interest in the signaling events initiated by surface receptor engagement. We have been particularly interested in ...
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The research in the Lammerding laboratory is focused on developing novel experimental techniques to investigate the interplay between cellular mechanics and function, with a particular emphasis on the cell nucleus and its response to ...
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Research in my group is focused on the evolutionary genomics of insect-pathogen interactions, emphasizing such questions as how natural selection operates on host immune systems, why individuals vary in susceptibility or resistance to infection, ...
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There is a fine balance between appropriate, host-protective, immune responses and dysregulated autoimmune and pathologic inflammation. The Leifer lab investigates how immune responses are induced and regulated with the hope of developing treatments to ...
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Studying host-parasite interactions that involves disciplines like pathology, immunology, molecular biology and gastroenterology. Developing diagnostics for veterinary parasites/pathogens. Studying biodiversity of parasites of North American wildlife.
My lab tries to understand regulatory mechanisms of protein function, such as protein post-translational modifications and allosteric modulation, and to use the understanding to develop potential therapeutics for treating human diseases, including immune diseases.
