The mammalian gastrointestinal tract is colonized with diverse commensal microbial communities consisting of bacteria, fungi and viruses. The Iliev Laboratory studies the interaction between this commensal microbiota and the immune cells at the mucosal ...
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Our laboratory studies “tissue homeostasis” the deliberate and balanced equilibrium that the immune system must achieve in order to both enforce self-tolerance to our own tissues, while at the same time remaining poised to ...
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Research in the Cubillos-Ruiz lab aims at understanding how Endoplasmic Reticulum (ER) stress responses sculpt immune cell function in health and disease. Our lab focuses on uncovering and characterizing the immunometabolic and epigenetic programs ...
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Regulation of Myelo- monopoiesis by chemo lines and hormones including retinoic acid
The Shen Lab lab investigates the genetic, epigenetic and metabolic mechanisms of cancer evolution. Our research is focused on understanding the role of PTEN in protecting the genome, maintaining chromatin architecture, suppressing tumorigenesis, and ...
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My lab aims at exploring the immune-metabolic role of radiation therapy and to define the impact of TGFb and activin A in the radiation response of glioblastomas.
We explore epigenetic mechanisms that are required to drive the humoral immune response, and how disruption of these mechanisms cause malignant transformation into lymphomas.
We investigate (1) how UBR5, a novel protein ubiquitin ligase frequently altered in human cancers, promotes tumor metastasis by regulating epithelial to mesenchymal transition (EMT) in a cell intrinsic manner;(2) to identify UBR5’s E3 ...
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My research focuses on deciphering the role of exosomes in mediating the crosstalk between the host immune system and the tumor, and the mechanisms through which exosomes coax the immune system to contribute to ...
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The current interest of our team is to elucidate the links between cellular pathways of response to stress – including (but not limited to) autophagy, cellular senescence and multiple variants of regulated cell death ...
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