Although immune checkpoint blockade therapy has revolutionized cancer treatment, a subset of tumors, such as those of the breast, are still largely unresponsive. The Dongre Lab is focused on understanding mechanisms that can potentiate ...
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Research in the Cubillos-Ruiz lab aims at understanding how Endoplasmic Reticulum (ER) stress responses sculpt immune cell function in health and disease. Our lab focuses on uncovering and characterizing the immunometabolic and epigenetic programs ...
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We use integrated preclinial and clinical investigations to determine the contribution of the tumor reprogramed immune microenvironments in lung cancer and breast cancer. We are investigating modalities including subablative radiation and agents that target ...
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My research focuses on deciphering the role of exosomes in mediating the crosstalk between the host immune system and the tumor, and the mechanisms through which exosomes coax the immune system to contribute to ...
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