Development of the adaptive immune response and integration of DNA damage responses and immune responses.
I am interested in host pathogen interactions in human retrovirus infections, including HIV-1 and human endogenous retroviruses.
Our laboratory has had a longstanding interest in understanding the molecular mechanisms employed by lymphocytes to accurately respond to the signals that guide them along specific pathways.
My lab is focused on understanding basic principles of immunity against infection and age-related changes that alter immune responses in early life. We also are interested in determining how environmental factors (maternal diet, microbiome, ...
We study the biology of Mycobacterium tuberculosis and HIV-1 infections in the context of our evolving appreciation of myeloid cell heterogeneity in vivo. Our studies extend to human subject analysis in Malawi and South ...