Immune memory occurs when the immune system remembers previous encounters with pathogens, aberrant cells, or self-antigens to produce a more rapid or robust secondary response upon re-encounter. It stands as the cornerstone of vaccine ...
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My current research explores epigenetic and environmental mechanisms of disease in the setting of the immune system with emphasis on the metabolic disease and interactions with infectious and neurological disease.
The Mason laboratory develops and deploys computational and experimental methodologies to identify the functional genetic elements of the human genome and metagenome. To do this, we perform research in three principal areas: (1) molecular ...
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We explore epigenetic mechanisms that are required to drive the humoral immune response, and how disruption of these mechanisms cause malignant transformation into lymphomas.
(1) Histone functional genetic models to study epigenetic regulation of mouse hematopoiesis and immune cell development. (2) Mechanisms and function of epigenetic memory of inflammation in hematopoietic stem cells. (3) “Signaling to chromatin” and ...
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