Laura Santambrogio
Associate Director of Precision Immunology in the Englander Institute of Precision Medicine, Professor of Physiology, Biophysics and Radiation Oncology
Radiation Oncology, The Caryl and Israel Englander Institute for Precision Medicine
Weill Cornell Medical - New York City
Interests: Dendritic Cells, MHC-restricted antigen processing and presentation
I am currently the Associate Director of Precision Immunology in the Englander Institute of Precision Medicine and Professor of Physiology, Biophysics and Radiation Oncology at Weill-Cornell Medicine. Current efforts in my laboratory are focused on the different mechanisms of antigen processing and presentation, peptide binding to MHC class II molecules and the overall role of dendritic cells in the innate and adaptive immune response. We are tackling these questions using and integrated approach that combine cell biology, biochemistry and biophysics. Important questions addressed by my laboratory relate to the different cellular pathways utilized for antigen processing and presentation which include autophagy, endosomal processing and surface MHC II loading. All these pathways generate different set of peptides from the same protein, expanding the number of presented epitopes for maintenance of central and peripheral tolerance. Additionally, my laboratory has been the first to perform the proteomic analysis of the human lymph and is currently involved in understanding the role of the lymphatic fluid and lymphatic endothelial cells in immunological tolerance as well as immunity to pathogens. Complete List of Published Work in My Bibliography: https://www.ncbi.nlm.nih.gov/pubmed/?term=santambrogio+laura
